Anti-C2orf3 /FITC抗体 Anti-C2orf3 /FITC

Anti-C2orf3 /FITC抗体

产品编号YB-15014R-FITC

英文名称Anti-C2orf3 /FITC

中文名称FITC标记的2号染色体开放阅读框3抗体

别    名Chromosome 2 open reading frame 3; DNABF; GC rich sequence DNA binding factor; GCF; TCF 9; TCF9; Transcription factor 9; GCFC2_HUMAN.

Anti-C2orf3 /FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  染色质和核信号  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Cow,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量89kDa

Anti-C2orf3 /FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

*** 原KLH conjugated synthetic peptide derived from human C1orf125

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-C2orf3 /FITC抗体

产品介绍background:

GCF (GC-rich sequence DNA-binding factor), also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of β-Actin, EGFR and calcium-dependent protease (CANP) promoters. GCF contains multiple phosphoserine and phosphothreonine residues, and two GCF isoforms are produced due to alternative splicing events. GCF is considered a candidate for susceptibility to dyslexia (DYX3) as both genes reside in close proximity on human chromosome 2. Chromosome 2 is the second largest human chromosome and consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome.

Function:

Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters.

Subcellular Location:

Nucleus.

Tissue Specificity:

Widely expressed in tissues and cell lines.

Similarity:

Belongs to the GCF family.

Database links:

UniProtKB/Swiss-Prot: P16383.2

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.