Anti-kappa Opioid receptor/FITC抗体 Anti-kappa Opioid receptor/FITC
产品简介
Anti-kappa Opioid receptor/FITC抗体和抗原之间的结合具有高度的特异性,**组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来,以此作为抗原或半抗原,Anti-kappa Opioid receptor/FITC抗体通过**动物后获得特异性的抗体,再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的,因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来,以其达到对组织或细胞中的未知抗原进行定性,定位或定量的研究。
产品详细信息
Anti-kappa Opioid receptor/FITC抗体
产品编号YB1094R-FITC
英文名称Anti-kappa Opioid receptor/FITC
中文名称FITC标记的kappa型**受体抗体
别 名Kappa type opioid receptor; KOR 1; KOR; Opiate receptor kappa 1; OPRK 1; OPRK; OPRK1; Oprk2; R21; OPRK_HUMAN.
Anti-kappa Opioid receptor/FITC抗体
说 明 书100ul
研究领域细胞生物 **学 神经生物学 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
Anti-kappa Opioid receptor/FITC抗体性 状Lyophilized or Liquid
浓 度1mg/ml
*** 原KLH conjugated synthetic peptide derived from human kappa Opioid receptor
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-kappa Opioid receptor/FITC抗体
产品介绍background:
Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors. The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.
Function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Subunit:
Interacts with SLC9A3R1. Anti-kappa Opioid receptor/FITC抗体Interacts with GABARAPL1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 4986 Human
Omim: 165196 Human
SwissProt: P41145 Human
Unigene: 106795 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
kappa型**受体在人脑和胎盘组织中有分布。κ- 受体参与镇痛 ,且与神经***及**调节有关。此外,κ受体也调控****样脊髓镇痛、**和瞳孔缩小。κ-**受体由380个氨基酸组成,同样属于G蛋白偶联受体家族。