神经肽Y抗体

神经肽Y抗体

规格：1mg/1ml

英文名： Neuropeptide Y

别名： Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; Pro-neuropeptide Y; NPY_HUMAN.

分子量： 4/8kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human NPY

交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,

神经肽Y抗体细胞定位：分泌型蛋白

产品介绍：background: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Neuropeptide Y (NPY) is a 36 amino acid peptide 神经肽Y抗体neurotransmitter found in the brain and autonomic nervous system. NPY has been associated with a number of physiologic processes in the brain, including the regulation of energy balance, memory and learning, and epilepsy.The main effect is increased food intake and decreased physical activity. NPY is secreted by the hypothalamus, and in addition to increasing food intake, it increases the proportion of energy stored as fat and blocks nociceptive signals to the brain NPY also augments the vasoconstrictor effects of noradrenergic neurons. Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Subcellular Location: Secreted. Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. Post-translational modifications: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Similarity: Belongs to the NPY family. Gene ID: 4852 Database links: Entrez Gene: 396464 Chicken Entrez Gene: 504216 Cow Entrez Gene: 4852 Human Entrez Gene: 109648 Mouse Entrez Gene: 397304 Pig Entrez Gene: 神经肽Y抗体24604 Rat Omim: 162640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白 神经肽Y是一种神经传导因子，参与机体的应急反应， 在应激状态下-NPY升高;他还可以促进血小板聚集、白细胞粘附及 巨噬细胞活化而参 与**反应 神经肽Y广泛分布于动物**和外周神经元及机体组织、器官和腺体内 ,影响动物采食、**分泌、心血管效应、调节体温、生物节律、性行为及动物情绪等多种功能。 由于结构中富含酪氨酸 ,故称为神经肽酪氨酸 (NPY)。它的结构与同是 36个氨基酸的胰多肽 (pp)和肽 YY(PYY)极其相似 ,故认为同属胰多肽家族。从分子结构看 ,人、大鼠、豚鼠和兔序列**一致 ,而牛、羊、猪 NPY序列与人的序列只相差一个氨基酸。

神经肽Y抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  信号转导  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid