一氧化氮合酶转运诱导抗体 NOSTRIN

一氧化氮合酶转运诱导抗体

规格：1mg/1ml

英文名： NOSTRIN

别名： BM247; BM247 homolog; DaIP2; eNOS-trafficking inducer; mDaIP2; MGC20702; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; NOSTN_HUMAN; Nostrin; RP23-431D4.2

分子量： 58kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human NOSTRIN

交叉反应：Human, Mouse, Rat, Rabbit,

细胞定位：细胞膜

一氧化氮合酶转运诱导抗体产品介绍：background: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation 一氧化氮合酶转运诱导抗体of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain. Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Subcellular Location: Cell membrane. Cytoplasmic vesicle. Cytoplasm > cytoskeleton. Enriched in 一氧化氮合酶转运诱导抗体selected actin structures. Tissue Specificity: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). Similarity: Contains 1 FCH domain. Contains 1 SH3 domain. Gene ID: 115677 Database links: Entrez Gene: 115677 Human Entrez Gene: 329416 Mouse Omim: 607496 Human SwissProt: Q8IVI9 Human SwissProt: Q6WKZ7 Mouse Unigene: 189780 Human Unigene: 90047 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

一氧化氮合酶转运诱导抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  转运蛋白  跨膜蛋白  细胞膜蛋白  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid