EIF3S4蛋白抗体 EIF3S4

EIF3S4蛋白抗体

规格：1mg/1ml

英文名： EIF3S4

别名： 44kDa; Anti EIF3S4; eIF 3 delta; eIF 3 RNA binding subunit; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 delta; eIF3 p42; eIF3 p44; eIF3g; EIF3G_HUMAN; EIF3S4; EIF3S4; ; Eukaryotic translation initiat

分子量： 36kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human EIF3S4

交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,

细胞定位：细胞核 细胞浆

EIF3S4蛋白抗体产品介绍：background: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in severalEIF3S4蛋白抗体 cancers, suggesting a role for eIF3 proteins in tumorigenesis. Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly EIF3S4蛋白抗体and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Colocalizes with AIFM1 in the nucleus and perinuclear region. Post-translational modifications: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. Similarity: Belongs to the eIF-3 subunit G family. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 8666 Database links: Entrez Gene: 8666 Human Entrez Gene: 53356 Mouse Entrez Gene: 298700 Rat Entrez Gene: 393974 Zebrafish Omim: 603913 Human SwissProt: Q3ZC12 Cow SwissProt: O75821 Human SwissProt: Q9Z1D1 Mouse SwissProt: Q5RK09 Rat SwissProt: Q6DRC4 Zebrafish Unigene: 529059 Human Unigene: 427309 Mouse Unigene: 107880 Rat Unigene: 161 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EIF3S4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  表观遗传学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid