组织蛋白酶B抗体 Cathepsin B

组织蛋白酶B抗体

规格：1mg/1ml

英文名： Cathepsin B

别名： Amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; CB; Cathepsin B1; CathepsinB; CPSB; CTSB; Cysteine protease; Preprocathepsin B; Cathepsin B heavy chain; Cathepsin B light chain;

分子量： 23/28/37kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human Cathepsi

交叉反应：Human, Mouse, Rat,

细胞定位：细胞浆

组织蛋白酶B抗体产品介绍：background: The protein encoded by this gene is a lysosomal cysteine proteina******posed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Function: Thiol protease which is believed to participate in intracellular 组织蛋白酶B抗体degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Subcellular Location: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the peptidase C1 family. Gene ID: 1508 Database links: Entrez 组织蛋白酶B抗体Gene: 1508 Human Entrez Gene: 13030 Mouse Entrez Gene: 64529 Rat Omim: 116810 Human SwissProt: P07858 Human SwissProt: P10605 Mouse SwissProt: P00787 Rat Unigene: 520898 Human Unigene: 236553 Mouse Unigene: 472420 Mouse Unigene: 100909 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） 组织蛋白酶B(CB) 参与肿瘤的侵袭转移过程。可促进肿瘤血管的增生，增强肿瘤细胞的运动能力.组织蛋白酶B转录以及表达水平的高低与肿瘤预后呈正相关。 cathepsin B属于半胱氨酸蛋白酶,与人体的多种生理、病理过程密切相关.组织蛋白酶B (cathepsin B,CB)主要存在于溶酶体中, 发挥其生理状态下的蛋白水解作用.但在某些特定条件下, CB在胞外间质中有时也可以检测到. 目前，有学者将CB用于阿尔茨海默病（AD）方面的研究。

组织蛋白酶B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  **学  合成与降解  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid