抗凝血酶3抗体 Antithrombin III /SERPINC1

抗凝血酶3抗体

规格：1mg/1ml

英文名： Antithrombin III /SERPINC1

别名： AntithrombinIII; Antithrombin III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C

分子量： 51kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human Antithro

交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,

细胞定位：分泌型蛋白

抗凝血酶3抗体产品介绍：background: The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. Function: Most important serine protease 抗凝血酶3抗体inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subunit: Forms protease inhibiting heterodimer with TMPRSS7.抗凝血酶3抗体 Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Phosphorylation sites are present in the extracellular medium. Similarity: Belongs to the serpin family. Gene ID: 462 Database links: Entrez Gene: 462 Human Entrez Gene: 11905 Mouse Entrez Gene: 304917 Rat Omim: 107300 Human SwissProt: P01008 Human SwissProt: P32261 Mouse Unigene: 75599 Human Unigene: 260770 Mouse Unigene: 204806 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

抗凝血酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  细胞生物  **学  合成与降解  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid