磷酸化肌球蛋白调节轻链MRLC3抗体 phospho-MRCL3 (Thr18 + Ser19)

磷酸化肌球蛋白调节轻链MRLC3抗体

规格：1mg/1ml

英文名： phospho-MRCL3 (Thr18 + Ser19)

别名： MRCL3 (phospho T18 + S19); ML12A_HUMAN; MLC 2B; MLC-2B; MLCB; MYL12A; Myosin regulatory light chain 12A; Myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulat

分子量： 20kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthesised phosphopeptide derived from human

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep,

细胞定位：细胞浆

磷酸化肌球蛋白调节轻链MRLC3抗体产品介绍：background: Myosin is a highly conserved, ubiquitously expressed protein that interacts with Actin to generate the force for cellular movements. Conventional myosins are hexameric proteins consisting of two heavy chain subunits, a pair of non-phosphorylatable light chain subunits and a pair of phosphorylatable light chain subunits. Three general classes of myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Myosin regulatory light chains, including MRCL3 (also known as MRLC3 or MLCB), MRLC2 (also known as MLC-B) and MYL9 (also known as LC20, MLC2, MRLC1 or MYRL2), regulate contraction in smooth muscle and non-muscle cells via phosphorylation by myosin light chain kinase (MLCK). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the Actin-activated myosin ATPase activity, thereby regulating the contractile 磷酸化肌球蛋白调节轻链MRLC3抗体activity. Myosin light chain is also located in striated skeletal muscle, where its function remains undefined. Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Post-translational modifications: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary 磷酸化肌球蛋白调节轻链MRLC3抗体for localization of myosin-2 at the leading edge. Similarity: Contains 3 EF-hand domains. Gene ID: 10627 Database links: Entrez Gene: 10627 Human Entrez Gene: 67268 Mouse SwissProt: P19105 Human Unigene: 190086 Human Unigene: 261329 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷酸化肌球蛋白调节轻链MRLC3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  心血管  细胞生物  信号转导  细胞骨架  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid