多聚**球蛋白受体抗体/Anti-PIGR 货号bs-6061R
产品简介
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产品详细信息
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 hu
产品类型 一抗
研究领域 **学 **荧光 流氏细胞检测
蛋白分子量 predicted molecular weight: 83kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
*** 原 KLH conjugated synthetic peptide derived from human PIGR
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
多聚**球蛋白受体抗体/Anti-PIGR 产品介绍 PIGR is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
多聚**球蛋白受体(pIgR)属Ⅰ型跨膜糖蛋白,可与多聚**球蛋白A和多聚**球蛋白M特异性结合,通过穿胞转运,将它们从上皮细胞基底侧膜转运到顶膜,并*终分泌到外分泌液中去. 在此过程中,多聚**球蛋白受体的细胞外段被水解,释放出与多聚**球蛋白A或多聚**球蛋白M相结合的细胞外段(又称为分泌成分). 分泌成分是sIgA分子的重要组成部分,直接参与sIgA的粘膜防御功能,而且在被动粘膜**中也有重要作用. 多聚**球蛋白受体通过介导细胞内多聚**球蛋白的转运,可以在粘膜的腔面阻止病原体粘附,在上皮细胞内中和病毒,也可以将固有层内的抗原分泌出去.