动物精细行为分析系统

系统介绍

动物精细行为分析系统是Gene&I联合国外厂商推出的针对于复杂**表现进行分析的展品，也是动物行为分析的旗舰产品，代表了动物行为分析的*高水平。

产品可自动分析动物日常行为的23种身体行为，并可将分析的行为进行分类统计。针对于帕金森、神经性舞蹈症、阿尔兹海默症、疯牛病等一些无法使用单一指标进行评价的**，可通过对动物某一些身体行为异常改变的统计分析来进行评价。

产品具有两个版本。HomecageScan是针对于大小鼠日常行为分析的版本；PrimateScan是针对于灵长类动物进行日常行为分析的版本。

可分析动物直立身体、回降身体、向左走、向右走、吃、喝、咀嚼、清理身体、排尿、垂直悬吊、偎着笼子悬吊、垂直降落、跳跃、转动、转圈、睡觉、痉挛、觉醒、 挖掘找寻粮食、嗅、闻、间歇停顿 、伸懒腰等行为。

系统特点

动物行为分析的*高水平

全自动动物精细自然行为分析

昼夜节律分析

实时分析和回放分析两种选择

24小时以上连续摄像

具有双击活动事件进行事件发生视频片段回放功能

实验过程中动物行为详细的统计信息

多区域版本可进行四个笼子同时分析

对实验背景要求低，颜色对比不明显也可准确判断各种行为

系统介绍

生物节律                                                                            毒理学研究

神经性舞蹈症（Huntington Disease）                               进食/饮水研究

Prion Disease                                                                    肥胖/代谢**研究

狂躁症（Mania）                                                               慢性/自发疼痛研究

**过程观察                                                                     运动缺陷研究

遗传研究                                                                            衰老研究

Phenotypic arrays of HD and PrD behaviors over time. Meanvalues for HD(A) or PrD (B) were divided by mean control values to give the fold increase or decrease in the behaviors listed. The fold increase or decrease is indicated in the figure as increasing intensity of blue for negative fold changes or yellow for positive fold changes

Andrew D. Steele, Walker S. Jackson, Oliver D. King, and Susan Lindquist. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. 

Reference

E.B. Adamah-Biassi, I. Stepien, R.L. Hudson, M.L. Dubocovich (2013), Automated Video Analysis System Reveals Distinct Diurnal Behaviors in C57BL/6 and C3H/HeN Mice, Behavioural Brain Research, Volume 243, 15 April 2013, Pages 306–312.

Miki Hiasa, Yumiko Isoda, Yasushi Kishimoto, Kenta Saitoh, Yasuaki Kimura, Motomu Kana, MasakatsuShibasaki, Dai Hatakeyama, Yutaka Kirino, Takashi Kuzuhara, (2013), Inhibition of monoamine oxidase A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir, British Journal of Pharmacology, 2013.

Kyzar, M Pham, A Roth, J Cachat, J Green, S Gaikwad, and AV Kalueff, (2012) Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes, Brain Res Bull, Dec 2012; 89(5-6): 168-76.

NC Lee, YD Shieh, YH Chien, KY Tzen, I Yu, PW Chen, (2012) Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency, Neurobiology of Disease, Available online 26 December 2012.

Yasushi Kishimoto, ErinaHigashihara,AkikoFukuta, Akira Nagao, Yutaka Kirino, (2012) Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease, Brain Research, Available online 7 November 2012.

Gillian Hamilton and Thomas H. Gillingwater, (2012) Spinal muscular atrophy: going beyond the motor neuron, TRMOME-835; No. of Pages 11.