MPEG2000-Silane,甲氧基聚乙二醇硅烷,PS1-L-2K,ponsure

结构式： 

基本信息：

中文名称：甲氧基聚乙二醇硅烷(MPEG-Silane)

中文别名：甲氧基-PEG-硅烷

英文名称：MPEG-Silane

CAS：-

分子量：350、500、550、750、1K、2K、5K、10K、20K

纯度：95%以上

应用简介：

Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Reaction Procedures:

Generally, silane PEG is first dissolved in a mixture of ethanol/water solution, then allow the solution to contact with oxidized glass or silica surface for 30 min to 2 hours. Under this condition, silane PEG should bind to the material covalently.

Materials Required:

Pegylation solution: Ethanol/water (w/w, 95%/5%);

Silane PEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.

Washing solution: Distilled water.

Reaction Steps:

1. Dissolve targeted materials in Pegylation buffer.

2. Add silane PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG needed for optimal conjugation;

3. Allow mixture agitates at room temperature for 30 min at room temperature or 2 hours at 4 -20℃.

4. Wash out unreacted materials either by distilled water.

物理性质：

状态：液体或者固体，取决于分子量。

溶解性：溶于DMSO,DMF,DCM。

保持条件：-20℃长期保存，避光，干燥。

注意事项：取用一定要干燥，避免频繁的溶解和冻干。

技术指标：

纯度（PEG）：95%以上

取代率（SIL）：90%以上

分散系数（PDI）：小于等于1.05

分析：COA、GPC、NMR、MALDI-TOF

（接受特殊分子量的定制：350、550、500、750）

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