Anti-Apaf1 Interacting Protein抗体

Cat. Number:

Anti-Apaf1 Interacting Protein抗体KL-6792R

Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The mammalian Anti-Apaf1 Interacting Protein抗体homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most ***** tissue with high expression in skeletal muscle, heart, and kidney.

Also known as:

MTNB_HUMAN; Apaf1Anti-Apaf1 Interacting Protein抗体 Interacting Protein; APIP2; CG129; CGI 29; MMRP19; MTRu 1 P dehydratase; Probable methylthioribulose 1 phosphate dehydratase.

Specificity:

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be Anti-Apaf1 Interacting Protein抗体determined by the end user.