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- 产品名称:Anti-phospho-Ataxin-1 (Ser238)抗体
- 产品型号:磷酸化失调症蛋白1抗体
- 产品展商:KALANG
- 产品文档:无相关文档
- 发布时间:2016-05-12
- 在线询价
简单介绍
Anti-phospho-Ataxin-1 (Ser238)抗体产品质量稳定,实验效果明显,货期快,价格优惠,欢迎垂询订购!我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-phospho-Ataxin-1 (Ser238)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
产品描述
Rabbit Anti-phospho-Ataxin-1 (Ser238)
Cat. Number:
Anti-phospho-Ataxin-1 (Ser238)抗体KL-8597R
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative Anti-phospho-Ataxin-1 (Ser238)抗体disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1).
Also known as:
Anti-phospho-Ataxin-1 (Ser238)抗体Ataxin-1 (phospho-Ser238); Ataxin-1 (phospho S238); ATXN1; ATX1; D6S504E; SCA1; Ataxin-1; Spinocerebellar ataxia type 1; ATX1_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Dog, Horse, Rabbit, Guinea Pig, .
●
Immunogen: KLH conjugated synthesised phosphopeptide derived from human ATXN1 around the phosphorylation site of Ser238.
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Predicted Molecular Weight: 90kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 Anti-phospho-Ataxin-1 (Ser238)抗体 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working Anti-phospho-Ataxin-1 (Ser238)抗体dilutions must be determined by the end user.
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