Anti-BRCC4抗体

Cat. Number:

Anti-BRCC4抗体KL-5710R

Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs.Anti-BRCC4抗体 Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promoteAnti-BRCC4抗体 tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Also known as:

Brain and reproductive organ expressed (TNFRSF1A modulator); BRCA1/BRCA2 containing complex subunit 4;Anti-BRCC4抗体 BRCA1/BRCA2 containing complex subunit 45; BRCC4; BRCC45; BRE_HUMAN.

Specificity:

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500 Anti-BRCC4抗体 ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.