Anti-Phospho-Bcr (Tyr360)抗体

Cat. Number:

Anti-Phospho-Bcr (Tyr360)抗体KL-6258R

Quantity size:

0.1ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in Anti-Phospho-Bcr (Tyr360)抗体patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have Anti-Phospho-Bcr (Tyr360)抗体been found for this gene.

Also known as:

Bcr (phospho Y360); Bcr(phospho Y360); P-Bcr(phospho Y360); ALL; BCR 1; BCR/ABL FUSION GENE INCLUDED; BCR/FGFR1 FUSION GENE INCLUDED; BCR/PDGFRA FUSION GENE INCLUDED; BCR1;Anti-Phospho-Bcr (Tyr360)抗体 breakpoint cluster region; CML; PHL; BCR_HUMAN.

Specificity:

Storage:

Shipped at 4℃, Anti-Phospho-Bcr (Tyr360)抗体Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.