- 如果您对该产品感兴趣的话，可以
- 产品名称：Anti-Rb抗体
- 产品型号：成视网膜细胞瘤基因抗体
- 产品展商：KALANG
- 产品文档：无相关文档
- 发布时间：2018-08-10
- 在线询价
简单介绍
Anti-Rb抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-Rb抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
产品描述
Rabbit Anti-Rb
Cat. Number:
Anti-Rb抗体KL-2777R
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure.Anti-Rb抗体 The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Also known as:
Including osteosarcoma; OSRC; Anti-Rb抗体Osteosarcoma; P105 RB; p105-Rb; P105RB; PP105; PP110; PPP1R130; pRb; pRb; Prepro retinoblastoma associated protein; Protein phosphatase 1 regulatory subunit 130; RB 1; Rb; RB_HUMAN; RB1; RB1 gene; RB1 protein; Retinoblastoma 1 (including osteosarcoma); Retinoblastoma 1; Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, .
●
Immunogen: KLH conjugated syntheticAnti-Rb抗体 peptide derived from human P105 RB.
●
Predicted Molecular Weight: 102kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:100-500
Not yet tested in other applications. Anti-Rb抗体
Optimal working dilutions must be determined by the end user.
