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- 产品名称：Anti-RNASE2抗体
- 产品型号：嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经**抗体
- 产品展商：KALANG
- 产品文档：无相关文档
- 发布时间：2018-09-13
- 在线询价
简单介绍
Anti-RNASE2抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-RNASE2抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
产品描述
Rabbit Anti-RNASE2
Cat. Number:
Anti-RNASE2抗体KL-10606R
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Human and animal eosinophils contain a powerful neurotoxin that causes selective neuronal and axonal damage to white matter of cerebellum and spinal cord of experimental animals when injected intrathecally. This reaction is termed the "Gordon phenomenon." We purified the eosinophil-derived neurotoxin from eosinophil-rich leukocyte suspensions or eosinophil granules from four patients with various hypereosinophilic Anti-RNASE2抗体syndromes. A single protein with an average molecular weight of 18,400 was isolated by sequential chromatography on Sephadex G-50 columns and analyzed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis of column fractions. The purified eosinophil-derived neurotoxin from the cells of these patients retained the potent neurotoxic activity of the crude eosinophil or eosinophil granule extracts in experimental animals. These animals developed the syndrome of stiffness and ataxia progressing to severe paralysis characteristic of the Gordon phenomenon. Histologic examination of the brains of animals injected with purified eosinophil-derived neurotoxin confirmed the characteristic widespread loss of Purkinje cells and severe spongiform vacuolation in the white matter of cerebellum, brain stem, and spinal cord. We have established the location of eosinophil-derived neurotoxin in the eosinophil granule and have shown that it is distinct from several other eosinophil proteins, the granule major basic protein, and the Charcot-Leyden crystal protein (lysophospholipase).
Also known as:
RNASE2; EDN; RNS2; Anti-RNASE2抗体RNAS2_HUMAN; Non-secretory ribonuclease; Eosinophil-derived neurotoxin;; RNase UpI-2; Ribonuclease 2; RNase 2; Ribonuclease US; Ear4; EC=3.1.27.5; EDN; Eosinophil cationic type ribonuclease 4; MR 4; Non secretory ribonuclease; R14; R15; R5; Ribonuclease 2; Ribonuclease RNase A family 2 (liver eosinophil derived neurotoxin); Ribonuclease US; RNase 2; RNase UpI 2.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, .
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Immunogen: KLH conjugated syntheticAnti-RNASE2抗体 peptide derived from human RNASE2.
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Predicted Molecular Weight: 14kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 Anti-RNASE2抗体
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
