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- 产品名称：重组鼠白细胞介素-36α，153a.a.蛋白
- 产品型号：rMuIL-36α, 153a.a.
- 产品展商：KALANG
- 产品文档：无相关文档
- 发布时间：2018-07-06
- 在线询价
简单介绍
重组鼠白细胞介素-36α，153a.a.蛋白与其它公司提供的重组蛋白不同，rMuIL-36α, 153a.a.蛋白产品为采用CFS的无细胞麦胚蛋白合成系统表达出来的重组蛋白，可表达出对细胞有毒性、易被蛋白酶降解的蛋白；并获得具有良好的可溶性，并有翻译后修饰、从而部分具有功能的蛋白.同时独有的全自动蛋白纯化技术则简便高效，将蛋白纯化过程中对蛋白的损伤降低到*小程度.重组鼠白细胞介素-36α，153a.a.蛋白（全长序列）产品可用于Western Blot验证、抗体制备、蛋白检测、ELISA等试验中.
产品描述
重组鼠白细胞介素-36α，153a.a.蛋白
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Synonyms
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FIL1 epsilon, IL-1 epsilon, IL-1F6, IL-1H1
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Species
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重组鼠白细胞介素-36α，153a.a.蛋白Murine
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Accession
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Q9JLA2
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GeneID
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54448
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SDS-PAGE
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Reference
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重组鼠白细胞介素-36α，153a.a.蛋白1. Nicklin MJ, Barton JL, Nguyen M, et al. 2002. Genomics. 79:718-25.
2. Dinarello C, Arend W, Sims J, et al. 2010. Nat Immunol. 11:973.
3. Barksby HE, Lea SR, Preshaw PM, et al. 2007. Clin Exp Immunol. 149:217-25.
4. Smith DE, Renshaw BR, Ketchem RR, et al. 2000. J Biol Chem. 275:1169-75.
5. Dunn E, Sims JE, Nicklin MJ, et al. 2001. Trends Immunol. 22:533-6.
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Background
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重组鼠白细胞介素-36α，153a.a.蛋白Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36α is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. Notably, IL-36 alpha is the only novel IL-1 family member expressed on T-cells. Recombinant murine interleukin-36 alpha contains 153 amino acids residues which is a single non-glycosylated polypeptide. Specifically, 重组鼠白细胞介素-36α，153a.a.蛋白mouse IL-36α shares 83 % a.a. sequence identity with rat IL-36α, 54 – 60 % with human, rabbit, equine and bovine IL-36α.
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