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- 产品名称：AKT1 / AKT2 / AKT3 Antibody
- 产品型号：
- 产品展商：immunoclone
- 产品文档：无相关文档
- 发布时间：2018-07-09
- 在线询价
简单介绍
AKT1 / AKT2 / AKT3 Antibody迅速增长的产品线包括一抗、二抗、**测定及细胞检测试剂盒、蛋白/多肽、激动剂/拮抗剂/活化剂/抑制剂及裂解物等。AKT1 / AKT2 / AKT3 Antibody严格的质量控制和验证实验包括各种不同的应用：WB、细胞**荧光、**组化、流式细胞术、ELISA、CHIP、IP和peptide array。
产品描述
AKT1 / AKT2 / AKT3 AntibodyProduct Profile
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Product Name
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AKT1 / AKT2 / AKT3 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.1) Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738. Malabarba M G, et al. (1996) Biochem. J. 319:865-872. Hou J, et al. (1994) Science. 265:1701-1706. Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343. Takeda K, et al. (1996) Nature. 380: 627-630.
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Immunogen
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AKT1/AKT2/AKT3 (Ab-315/316/312) antibody was raised against a peptide sequence around aa.313~317/314~318/310~314 (P-E-Y-L-A) derived from Human AKT1/AKT2/AKT3.
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AKT1 / AKT2 / AKT3 AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHC
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Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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AKT1 / AKT2 / AKT3 AntibodyTarget Information
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Gene Symbol
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AKT1 AKT2 AKT3
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Alternative Names
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AKT
PKB
RAC
CWS6
PRKBA
PKB-ALPHA
RAC-ALPHA
P53
RAC-PK-alpha
Protein kinase B
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Molecular Weight(MW)
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60 kDa
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Tissue Specificity
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This antibody detects endogenous level of total AKT1/AKT2/AKT3 protein.
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AKT1 / AKT2 / AKT3 AntibodyDatabase Links
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Entrez Gene
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207 / 208 / 10000
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Protein Accession
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NP_001014431.1 / NP_001617.1 / NP_005456.1
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AKT1 / AKT2 / AKT3 AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AKT1/AKT2/AKT3 (Ab-315/316/312).
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Application Notes
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Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20˚C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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