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第7年
- 入驻时间: 2015-11-06
- 联系人:顾磊
- 电话:021-60514606
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- Email:shybio@126.com
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产品详情
简单介绍:
Anti-phospho-ATF2 (Ser322)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-phospho-ATF2 (Ser322)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍:
Rabbit Anti-phospho-ATF2 (Ser322)
Cat. Number:
YB5169R
Quantity size:
0.1ml
Concentration:
Anti-phospho-ATF2 (Ser322)抗体1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Anti-phospho-ATF2 (Ser322)抗体ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.
Also known as:
Anti-phospho-ATF2 (Ser322)抗体ATF2 (phospho Ser322); ATF2 (phospho S322); p-ATF2 (S322); p-ATF2 (Ser322); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_MOUSE.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated Synthesised phosphopeptide derived from mouse ATF2 around the phosphorylation site of Ser322.
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Predicted Molecular Weight: 55kDa.
Storage:
Anti-phospho-ATF2 (Ser322)抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-phospho-ATF2 (Ser322)抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
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yb138Mu01 丝氨酸棕榈酰转移酶长链碱性亚基1(SPTLC1)多克隆抗体 Polyclonal Antibody to Serine klmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Mus musculus (Mouse)
yb139Hu01 墨蝶呤还原酶(SPR)多克隆抗体 Polyclonal Antibody to Sepiapterin Reductase (SPR) Homo sapiens (Human)
yb142Hu01 丝氨酸肽酶抑制因子Kunitz型2(SPINT2)多克隆抗体 Polyclonal Antibody to Serine Peptidase Inhibitor Kunitz Type 2 (SPINT2) Homo sapiens (Human)
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