产品名称：Anti-phospho-ATF2 (Thr51)抗体

Cat. Number:

YB5172R

Quantity size:

0.1ml

Concentration:

Anti-phospho-ATF2 (Thr51)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Anti-phospho-ATF2 (Thr51)抗体ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Also known as:

Anti-phospho-ATF2 (Thr51)抗体ATF2(Phospho-Thr51); ATF2 (phospho Thr51); ATF2 (phospho T51); p-ATF2 (Thr51); p-ATF2 (T51); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.

Specificity:

Storage:

Anti-phospho-ATF2 (Thr51)抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Anti-phospho-ATF2 (Thr51)抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.yb178Hu01 N-磺氨基葡糖磺基氢化酶(SGSH)多克隆抗体 Polyclonal Antibody to N-Sulfoglucosamine Sulfohydrolase (SGSH) Homo sapiens (Human)
yb179Hu01 分层蛋白(SFN)多克隆抗体 Polyclonal Antibody to Stratifin (SFN) Homo sapiens (Human)
yb194Hu01 B类清道夫受体1(SCARB1)多克隆抗体 Polyclonal Antibody to Scavenger Receptor Class B Member 1 (SCARB1) Homo sapiens (Human)
yb234Hu01 核黄素激酶(RFK)多克隆抗体 Polyclonal Antibody to Riboflavin Kinase (RFK) Homo sapiens (Human)
yb244Hu01 网钙蛋白2(RCN2)多克隆抗体 Polyclonal Antibody to Reticulocalbin 2 (RCN2) Homo sapiens (Human)
yb244Mu01 网钙蛋白2(RCN2)多克隆抗体 Polyclonal Antibody to Reticulocalbin 2 (RCN2) Mus musculus (Mouse)
yb262Hu01 受体活性修饰蛋白2(RAMP2)多克隆抗体 Polyclonal Antibody to Receptor Activity Modifying Protein 2 (RAMP2) Homo sapiens (Human)
yb265Hu01 RalA结合蛋白1(RALBP1)多克隆抗体 Polyclonal Antibody to RalA Binding Protein 1 (RALBP1) Homo sapiens (Human)
yb274Hu01 谷氨酰胺酰肽环转移酶(QPCT)多克隆抗体 Polyclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT) Homo sapiens (Human)
yb280Hu01 垂体肿瘤转化1相互作用蛋白(PTTG1IP)多克隆抗体 Polyclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Homo sapiens (Human)
yb307Hu01 鱼精蛋白2(PRM2)多克隆抗体 Polyclonal Antibody to Protamine 2 (PRM2) Homo sapiens (Human)
yb314Hu01 cGMP依赖性蛋白激酶Ⅰ(PRKG1)多克隆抗体 Polyclonal Antibody to Protein Kinase, cGMP Dependent Type I (PRKG1) Homo sapiens (Human)
yb319Hu01 脯氨酸/精氨酸丰富端亮氨酸丰富重复蛋白(PRELP)多克隆抗体 Polyclonal Antibody to Proline Arginine Rich End Leucine Rich Repeat Protein (PRELP) Homo sapiens (Human)
yb334Hu01 旁血小板溶蛋白(PPL)多克隆抗体