产品名称：Anti-Aph-1b/FITC抗体

Anti-Aph-1b/FITC抗体

产品编号YB-11640R-FITC

英文名称Anti-Aph-1b/FITC

中文名称FITC标记的早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1抗体

别    名Anterior pharynx defective 1; Anterior pharynx defective 1 homolog B (C. elegans); Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; APH 1B; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; aph1b; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Gamma-secretase subunit Aph-1b; Presenilin stabilisation factor like; Presenilin-stabilization factor-like; PRO 1328; PRO1328; PSFL; TAAV 688; TAAV688.

Anti-Aph-1b/FITC抗体    

说 明 书100ul  

研究领域细胞生物  神经生物学  Alzheimer's  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Sheep,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量28kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Aph-1b

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Aph-1b/FITC抗体

产品介绍background:

Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.

Function:

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). Anti-Aph-1b/FITC抗体It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

Subunit:

Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity). Interacts with PSEN1 and PSEN2.

Subcellular Location:

Membrane; Multi-pass membrane protein

Tissue Specificity:

Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.

Similarity:

Anti-Aph-1b/FITC抗体Belongs to the APH-1 family.

Database links:

Entrez Gene: 83464 Human

Omim: 607630 Human

SwissProt: Q8WW43 Human

Unigene: 511703 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.