产品名称：Anti-Mint3/FITC抗体

Anti-Mint3/FITC抗体

产品编号YB-11058R-FITC

英文名称Anti-Mint3/FITC

中文名称FITC标记的β淀粉样前体蛋白结合蛋白3抗体

别    名Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; lin 10; MGC:15815; Mint 3; Mint3; Mint-3; Neuron specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2; APBA3_RAT.

Anti-Mint3/FITC抗体

说 明 书100ul  

研究领域**学  神经生物学  细胞粘附分子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Mouse, Rat,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量63kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from Rat Mint3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Mint3/FITC抗体

产品介绍background:

The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. Anti-Mint3/FITC抗体X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).

Function:

May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).

Subunit:

Anti-Mint3/FITC抗体Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity).

Subcellular Location:

Cytoplasm; perinuclear region.

Tissue Specificity:

Ubiquitous.

Similarity:

Contains 2 PDZ (DHR) domains.

Contains 1 PID domain.

Database links:

Entrez Gene: 57267 Mouse

Entrez Gene: 83611 Rat

SwissProt: O88888 Mouse

SwissProt: O70248 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.