产品名称：Anti-Amisyn/FITC抗体

Anti-Amisyn/FITC抗体

产品编号YB-11039R-FITC

英文名称Anti-Amisyn/FITC

中文名称FITC标记的突触融合结合蛋白6抗体

别    名Amisyn; HSPC156; STXB6_HUMAN; STXBP6; Syntaxin binding protein 6; Syntaxin-binding protein 6.

Anti-Amisyn/FITC抗体

说 明 书100ul  

研究领域神经生物学  细胞粘附分子  细胞外基质  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量24kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Amisyn

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Amisyn/FITC抗体

产品介绍background:

Amisyn is a mostly cytosolic protein related to Tomosyn which plays an important role in SNARE complex assembly. Amisyn contains a v-SNARE coiled coil homology domain that binds to Syntaxin 1A and weakly to Syntaxin 4. Three isoforms exist for Amisyn. Isoform 1 is the full length protein, isoform 2 has a different amino acid sequence between residues 204-210 and isoform 3 is missing amino acids 1-102 and contains a different sequence for amino acids 103-150. Amisyn lacks a transmembrane domain and therefore is unable to assemble into a functional, membrane-anchored SNARE complex. This suggests that Amisyn may instead be acting to maintain SNARE conformation and facilitate the binding of VAMP-2. Amisyn can inhibit exocytosis independent of Syntaxin binding.

Function:

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.

Subunit:

Part of a ternary complex containing SNAP25 and SAnti-Amisyn/FITC抗体TX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.

Subcellular Location:

Cytoplasm. Membrane.

Anti-Amisyn/FITC抗体Tissue Specificity:

Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.

Similarity:

Contains 1 v-SNARE coiled-coil homology domain.

Database links:

UniProtKB/Swiss-Prot: Q8NFX7.2

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.