产品名称：Anti-AT2R2/FITC抗体

Anti-AT2R2/FITC抗体

产品编号YB-2133R-FITC

英文名称Anti-AT2R2/FITC

中文名称FITC标记的血管紧张素Ⅱ受体2抗体

别    名AGTR 2; AGTR2; AGTR-2; AGTR2_HUMAN; angiotensin II receptor type 2; Angiotensin II Type 2; Angiotensin II type-2 receptor; Angiotensin receptor 2; AT 2; AT2; AT2R2 ATGR 2; ATGR2; ATGR-2; MRX 88; MRX88; Type 2 angiotensin II receptor; Type-2 angiotensin II receptor.

Anti-AT2R2/FITC抗体

说 明 书100ul  

研究领域心血管  细胞生物  信号转导  G蛋白偶联受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Sheep,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量41kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human angiotensin II receptor type 2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

Anti-AT2R2/FITC抗体

产品介绍background:

Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.

Function:

Receptor for angiotensin II. Anti-AT2R2/FITC抗体Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Subunit:

Interacts with MTUS1.

Subcellular Location:

Cell membrane.

Tissue Specificity:

In *****, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.

DISEASE:

Defects in AGTR2 are the cause of mental retardation X-linked type 88 (MRX88) [MIM:300852]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Similarity:

Belongs to the G-protein coupled receptor 1 family.

Anti-AT2R2/FITC抗体Database links:

Entrez Gene: 186 Human

Entrez Gene: 11609 Mouse

Entrez Gene: 24182 Rat

Omim: 300034 Human

SwissProt: P50052 Human

SwissProt: P35374 Mouse

SwissProt: Q3US12 Mouse

SwissProt: P35351 Rat

Unigene: 405348 Human

Unigene: 2679 Mouse

Unigene: 162367 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.