产品名称：Anti-phospho-ATF2 (Thr53)/FITC抗体

Anti-phospho-ATF2 (Thr53)/FITC抗体

产品编号YB-8449R-FITC

英文名称Anti-phospho-ATF2 (Thr53)/FITC

中文名称FITC标记的磷酸化活化复制因子2抗体

别    名ATF2(Phospho-Thr53); ATF2(Phospho-T53); p-ATF2(Thr53); p-ATF2(T53); CREB 2; HB 16; Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.

Anti-phospho-ATF2 (Thr53)/FITC抗体

说 明 书100ul  

产品类型磷酸化抗体

研究领域肿瘤  细胞生物  **学  信号转导  细胞凋亡  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Cow, Horse, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量54kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Thr53

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-phospho-ATF2 (Thr53)/FITC抗体

产品介绍background:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].

Function:

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.Anti-phospho-ATF2 (Thr53)/FITC抗体 Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.

Subunit:

Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

Subcellular Location:

Nucleus.

Tissue Specificity:

Abundant expression seen in the brain.

Post-translational modifications:

Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4.

Anti-phospho-ATF2 (Thr53)/FITC抗体Similarity:

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP domain.

Contains 1 C2H2-type zinc finger.

Database links:

Entrez Gene: 1386 Human

Entrez Gene: 100047997 Mouse

Entrez Gene: 11909 Mouse

Entrez Gene: 81647 Rat

Omim: 123811 Human

SwissProt: P15336 Human

SwissProt: P16951 Mouse

SwissProt: Q00969 Rat

Unigene: 592510 Human

Unigene: 209903 Mouse

Unigene: 9825 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.