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Anti-ATX2/FITC抗体
产品编号YB-7974R-FITC
英文名称Anti-ATX2/FITC
中文名称FITC标记的脊髓小脑共济失调2型蛋白抗体
别 名Ataxin 2; ATXN2; Olivopontocerebellar ataxia 2, autosomal dominant; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat containing gene 13 protein; SRRT_HUMAN.
Anti-ATX2/FITC抗体
说 明 书100ul
研究领域细胞生物 **学 神经生物学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量101kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ATX2 (771-815aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-ATX2/FITC抗体
产品介绍background:
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ATX2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. ATX2 is caused by expansion of a CAG repeat in the coding region of ATX2. Longer expansions result in earlier onset of the disease. There are four named isoforms.
Subunit:
Monomer. Can also form homodimers.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Anti-ATX2/FITC抗体Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Similarity:
Belongs to the ataxin-2 family.
Anti-ATX2/FITC抗体Database links:
Entrez Gene: 6311 Human
Entrez Gene: 20239 Mouse
Entrez Gene: 288663 Rat
Omim: 601517 Human
SwissProt: Q99700 Human
SwissProt: O70305 Mouse
Unigene: 76253 Human
Unigene: 260900 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.