产品名称：Anti-ASNA1/FITC抗体

Anti-ASNA1/FITC抗体

产品编号YB-7972R-FITC

英文名称Anti-ASNA1/FITC

中文名称FITC标记的砷酸盐转运三磷酸腺苷酶抗体

别    名ARSA 1; ARSA; ArsA arsenite transporter ATP binding homolog 1; ArsA arsenite transporter, ATP binding, E. coli, homolog of, 1; ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ARSA I; ARSA1; ARSAI; Arsenical pump driving ATPase; Arsenical resistance ATPase; Arsenite translocating ATPase; Arsenite transporting ATPase; Arsenite-stimulated ATPase; ASNA 1; ASNA I; Asna1 protein; ASNAI; ATPase Asna1; GET3; ASNA_HUMAN.

Anti-ASNA1/FITC抗体

说 明 书100ul  

研究领域细胞生物  信号转导  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Horse, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量39kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ASNA1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ASNA1/FITC抗体

产品介绍background:

ASNA1 is the human homolog of the E.coli arsA gene which is an ATPase, and is the catalytic component of a multisubunit oxyanion pump responsible for resistance to arsenicals and antimonials.

Function:

This gene represents the human homolog of the bacterialarsA gene, encoding the arsenite-stimulated ATPase component of thearsenite transporter responsible for resistance to arsenicals. Thisprotein is also a central component of a transmembrane domain (TMD)recognition complex (TRC) that is involved in thepost-translational delivery of tail-anchored (TA) proteins from thecytosol to the endoplasmic reticulum (ER). It recognizes andselectively binds the TMD of TA proteins in the cytosol, anddelivers them to the ER for insertion. [provided by RefSeq, Oct2011]. [FUNCTION] ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where thetail-anchored protein is released for insertion.Anti-ASNA1/FITC抗体 This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer reverts towardsthe open dimer state, lowering its affinity for the membrane-boundreceptor, and returning it to the cytosol to initiate a new roundof targeting (By similarity). May be involved in insulin signaling.

Subunit:

Homodimer (By similarity). Component of a transmembranedomain recognition complex (TRC) (By similarity). Interacts withSERP1 and SEC61B (By similarity). Interacts with WRB.

Subcellular Location:

Cytoplasm. Endoplasmic reticulum. Nucleus,nucleolus.

Anti-ASNA1/FITC抗体Tissue Specificity:

Expressed in the epithelial cells of theliver, kidney, and stomach wall, in the adrenal medulla, in theislet cells of the pancreas, in the red pulp of the spleen, and incardiac and skeletal muscle.

Similarity:

Belongs to the arsA ATPase family.

Database links:

Entrez Gene: 439 Human

Entrez Gene: 56495 Mouse

Entrez Gene: 288919 Rat

GenBank: NP_004308.2 Human

Omim: 601913 Human

SwissProt: O43681 Human

SwissProt: O54984 Mouse

Unigene: 465985 Human

Unigene: 41475 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.