产品名称：Anti-ANKRD13A/FITC抗体

Anti-ANKRD13A/FITC抗体

产品编号YB7963R-FITC

英文名称Anti-ANKRD13A/FITC

中文名称FITC标记的锚蛋白重复结构域蛋白13A抗体

别    名ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.

Anti-ANKRD13A/FITC抗体   

说 明 书100ul  

研究领域细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Cow, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量68kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ANKRD13A

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ANKRD13A/FITC抗体

产品介绍Function:

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Subunit:

Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.

Subcellular Location:

Cell membrane. Late endosome.Anti-ANKRD13A/FITC抗体 Note=Interaction with EGFR may enhance association with the cell membrane.

Post-translational modifications:

Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.

Similarity:

Contains 2 ANK repeats.

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Anti-ANKRD13A/FITC抗体Database links:

Entrez Gene: 88455 Human

Entrez Gene: 68420 Mouse

SwissProt: Q8IZ07 Human

SwissProt: Q80UP5 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.