产品名称：Anti-ANKRD28/FITC抗体

Anti-ANKRD28/FITC抗体

产品编号YB7926R-FITC

英文名称Anti-ANKRD28/FITC

中文名称FITC标记的锚蛋白重复域28抗体

别    名ANKRD 28; ANKRD-28; Ankyrin repeat domain 28; KIAA0379; Phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; ANR28_HUMAN.

Anti-ANKRD28/FITC抗体

说 明 书100ul  

研究领域细胞生物  信号转导  细胞周期蛋白  激酶和磷酸酶  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量113kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ANKRD28

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ANKRD28/FITC抗体

产品介绍background:

ANKRD28 selectively inhibits the phosphatase activity of PPP1C and targets PPP1C to modulate HNRPK phosphorylation. It contains twenty seven ANK repeats. There are two named isoforms.

Function:

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Subunit:

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).Anti-ANKRD28/FITC抗体 Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.

Subcellular Location:

Anti-ANKRD28/FITC抗体Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.

Similarity:

Contains 27 ANK repeats.

Database links:

UniProtKB/Swiss-Prot: O15084.5

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.