产品名称：Anti-ASB3/FITC抗体

Anti-ASB3/FITC抗体

产品编号YB-7736R-FITC

英文名称Anti-ASB3/FITC

中文名称FITC标记的锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体

别    名Ankyrin repeat and SOCS box containing 3; Ankyrin repeat and SOCS box containing protein 3; Ankyrin repeat and SOCS box protein 3; ASB-3; ASB3; ASB3_HUMAN; Weakly similar to ankyrin brain variant 2.

Anti-ASB3/FITC抗体

说 明 书100ul  

研究领域细胞生物  细胞周期蛋白  细胞分化  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Cow, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量57kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ASB3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ASB3/FITC抗体

产品介绍background:

Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the elongin B and C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat and SOCS box-containing (ASB) protein family are identified and termed as ASB-1, ASB-2, ASB-3 and ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells and its expression induces growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter.

Function:

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Anti-ASB3/FITC抗体 Recognizes TNFRSF1B.

Subunit:

Interacts with TCEB2 and TNFRSF1B.

Anti-ASB3/FITC抗体Similarity:

Contains 11 ANK repeats.

Contains 1 SOCS box domain.

Database links:

UniProtKB/Swiss-Prot: Q9Y575.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.