产品名称：Anti-ARTS1/FITC抗体

Anti-ARTS1/FITC抗体

产品编号YB-7643R-FITC

英文名称Anti-ARTS1/FITC

中文名称FITC标记的脂肪细胞源性亮氨酸氨基肽酶抗体（血管内皮细胞生长因子诱导蛋白）

别    名Endoplasmic reticulum aminopeptidase 1; A LAP; A-LAP; Adipocyte derived leucine aminopeptidase; Adipocyte-derived leucine aminopeptidase; ALAP; Aminopeptidase PILS; APPILS; ARTS 1; ARTS-1; Arts1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAP 1; Erap1; ERAP1_HUMAN; PILS AP; PILS-AP; PILSA; PILSAP; Puromycin insensitive leucyl specific aminopeptidase; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; VEGF-induced aminopeptidase.

Anti-ARTS1/FITC抗体

说 明 书100ul  

研究领域心血管  细胞生物  **学  信号转导  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量107kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ARTS1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ARTS1/FITC抗体

产品介绍background:

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Function:

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Anti-ARTS1/FITC抗体Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Subunit:

Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Subcellular Location:

Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable).

Anti-ARTS1/FITC抗体Tissue Specificity:

Ubiquitous.

Post-translational modifications:

N-glycosylated.

Similarity:

Belongs to the peptidase M1 family.

Database links:

Entrez Gene: 51752 Human

Entrez Gene: 80898 Mouse

Entrez Gene: 80897 Rat

Omim: 606832 Human

SwissProt: Q9NZ08 Human

SwissProt: Q9EQH2 Mouse

SwissProt: Q9JJ22 Rat

Unigene: 716426 Human

Unigene: 83526 Mouse

Unigene: 22516 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.