产品名称：Anti-AGTRAP/FITC抗体

Anti-AGTRAP/FITC抗体

产品编号YB-7642R-FITC

英文名称Anti-AGTRAP/FITC

中文名称FITC标记的血管紧张素Ⅱ受体相关蛋白抗体

别    名Angiotensin Ⅱ receptor associated protein; Angiotensin Ⅱ type I receptor associated protein; ATI receptor associated protein; ATRAP; MGC29646; Type 1 angiotensin Ⅱ receptor associated protein; ATRAP_HUMAN.

Anti-AGTRAP/FITC抗体

说 明 书100ul  

研究领域心血管  细胞生物  信号转导  G蛋白偶联受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量17kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human AGTRAP

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-AGTRAP/FITC抗体

产品介绍background:

AGTRAP (Angiotensin II receptor-associated protein) interacts with the angiotensin II type 1 receptor and negatively regulates type 1 angiotensin II receptor-mediated signaling, by regulating receptor internalisation as well as mechanisms of receptor desensitization such as phosphorylation.

Function:

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Subunit:

Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.

Subcellular Location:

Endoplasmic reticulum membrane; Multi-pass membrane protein. Anti-AGTRAP/FITC抗体Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Tissue Specificity:

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Anti-AGTRAP/FITC抗体Database links:

Entrez Gene: 57085 Human

Omim: 608729 Human

SwissProt: Q6RW13 Human

Unigene: 464438 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.