产品名称：Anti-phospho-AQP2(Ser264+261)/FITC抗体

Anti-phospho-AQP2(Ser264+261)/FITC抗体

产品编号YB4610R-FITC

英文名称Anti-phospho-AQP2(Ser264+261)/FITC

中文名称FITC标记的磷酸化水通道蛋白2抗体

别    名Aquaporin 2 (phospho S261); p-Aquaporin 2 (phospho S261) ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD.

Anti-phospho-AQP2(Ser264+261)/FITC抗体

说 明 书100ul  

产品类型磷酸化抗体

研究领域肿瘤  细胞生物  信号转导  通道蛋白  细胞粘附分子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量30kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human AQP2 around the phosphorylation site of Ser264/261

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-phospho-AQP2(Ser264+261)/FITC抗体

产品介绍background:

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Function:

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Subcellular Location:

Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane.

Tissue Specificity:

Expressed in renal collecting tubules.

Post-translational modifications:

Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.

DISEASE:

Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), Anti-phospho-AQP2(Ser264+261)/FITC抗体excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.

Similarity:

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Database links:

Entrez Gene: 359 Human

Entrez Gene: 11827 Mouse

Entrez Gene: 25386 Rat

Anti-phospho-AQP2(Ser264+261)/FITC抗体Omim: 107777 Human

SwissProt: P41181 Human

SwissProt: P56402 Mouse

SwissProt: P34080 Rat

Unigene: 130730 Human

Unigene: 20206 Mouse

Unigene: 90076 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.