产品名称：Anti-AQP0/FITC抗体

Anti-AQP0/FITC抗体

产品编号YB6661R-FITC

英文名称Anti-AQP0/FITC

中文名称FITC标记的水通道蛋白0抗体

别    名AQP 0; AQP0; Aquaporin; Aquaporin0; Lens fiber major intrinsic protein; LIM 1; LIM1; LIM-1; Major intrinsic protein 26kD; Major intrinsic protein of lens fiber; MIP 26; MIP; MIP26; MP 26; MP26; MIP_HUMAN.

Anti-AQP0/FITC抗体   

说 明 书100ul  

研究领域细胞生物  发育生物学  神经生物学  信号转导  干细胞  通道蛋白  细胞粘附分子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量29kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human AQP0

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-AQP0/FITC抗体

产品介绍background:

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein aquaporins. Aquaporin 0 or MIP26 (major intrinsic protein 26kD), and Aquaporin 1 has been the foundation of the growing family of aquaporins. The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein. Defects in Aquaporin 0 are a cause of autosomal recessive congenital cataract. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C terminus are predicted to be cytoplasmic.

Function:

Water channel. May be responsible for regulating the osmolarity of the lens. Anti-AQP0/FITC抗体Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Subunit:

Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. During early stages of lens development, interacts through its C-terminal region with Cx56 and GJA8/Cx45.6.

Subcellular Location:

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Tissue Specificity:

Major component of lens fiber gap junctions.

Similarity:

Anti-AQP0/FITC抗体Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Database links:

Entrez Gene: 4284 Human

Entrez Gene: 17339 Mouse

Entrez Gene: 25480 Rat

Omim: 154050 Human

SwissProt: P30301 Human

SwissProt: P51180 Mouse

SwissProt: P09011 Rat

Unigene: 574026 Human

Unigene: 31625 Mouse

Unigene: 396469 Mouse

Unigene: 23532 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.