产品名称：Anti-Adenosine deaminase/FITC抗体

Anti-Adenosine deaminase/FITC抗体

产品编号YB-6654R-FITC

英文名称Anti-Adenosine deaminase/FITC

中文名称FITC标记的腺苷脱氨酶抗体

别    名ada; ADA_HUMAN; Adenosine aminohydrolase; Adenosine deaminase.

Anti-Adenosine deaminase/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  信号转导  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow, Horse,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量40kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Adenosine deaminase

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Adenosine deaminase/FITC抗体

产品介绍background:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Function:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Subunit:

Interacts with DPP4 (extracellular domain).

Subcellular Location:

Cell membrane; Peripheral membrane protein; Anti-Adenosine deaminase/FITC抗体Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm.

Tissue Specificity:

Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.

DISEASE:

Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and *****s (late or ***** onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity who have partial ADA deficiency.

Anti-Adenosine deaminase/FITC抗体Similarity:

Belongs to the adenosine and AMP deaminases family.

Database links:

UniProtKB/Swiss-Prot: P00813.3

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.