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Anti-ABH8/FITC抗体
产品编号YB-6510R-FITC
英文名称Anti-ABH8/FITC
中文名称FITC标记的AlkB同源蛋白8抗体
别 名ABH8; alkB alkylation repair homolog 8 (E. coli); alkB alkylation repair homolog 8; AlkB homologue 8; ALKB8_HUMAN; ALKBH8; Alkylated DNA repair protein alkB homolog 8; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8.
Anti-ABH8/FITC抗体
说 明 书100ul
研究领域肿瘤 肿瘤细胞生物标志物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量75kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ABH8/ALKBH8 (256-300aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-ABH8/FITC抗体
产品介绍background:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in tRNA. Catalyzes the last step in the formation of5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA. Has a preference for tRNA(Arg) andtRNA(Glu), and does not bind tRNA(Lys). Anti-ABH8/FITC抗体Required for normalsurvival after DNA damage. May inhibit apoptosis and promote cellsurvival and angiogenesis.
Subunit:
Interacts with TRMT112.
Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantlycytoplasmic.
Tissue Specificity:
Widely expressed, with highest expression inspleen, followed by pancreas and lung.
Similarity:
Anti-ABH8/FITC抗体Belongs to the alkB family.
Contains 1 Fe2OG dioxygenase domain.
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 91801 Human
Entrez Gene: 67667 Mouse
Entrez Gene: 366783 Rat
Omim: 613306 Human
SwissProt: Q96BT7 Human
SwissProt: Q80Y20 Mouse
Unigene: 503763 Human
Unigene: 116968 Mouse
Unigene: 440994 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.