产品名称：Anti-ABH8/FITC抗体

Anti-ABH8/FITC抗体

产品编号YB-6510R-FITC

英文名称Anti-ABH8/FITC

中文名称FITC标记的AlkB同源蛋白8抗体

别    名ABH8; alkB alkylation repair homolog 8 (E. coli); alkB alkylation repair homolog 8; AlkB homologue 8; ALKB8_HUMAN; ALKBH8; Alkylated DNA repair protein alkB homolog 8; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8.

Anti-ABH8/FITC抗体

说 明 书100ul  

研究领域肿瘤  肿瘤细胞生物标志物  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量75kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ABH8/ALKBH8 (256-300aa)

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ABH8/FITC抗体

产品介绍background:

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.

Function:

Catalyzes the methylation of 5-carboxymethyl uridine to5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in tRNA. Catalyzes the last step in the formation of5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA. Has a preference for tRNA(Arg) andtRNA(Glu), and does not bind tRNA(Lys). Anti-ABH8/FITC抗体Required for normalsurvival after DNA damage. May inhibit apoptosis and promote cellsurvival and angiogenesis.

Subunit:

Interacts with TRMT112.

Subcellular Location:

Cytoplasm. Nucleus. Note=Predominantlycytoplasmic.

Tissue Specificity:

Widely expressed, with highest expression inspleen, followed by pancreas and lung.

Similarity:

Anti-ABH8/FITC抗体Belongs to the alkB family.

Contains 1 Fe2OG dioxygenase domain.

Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 91801 Human

Entrez Gene: 67667 Mouse

Entrez Gene: 366783 Rat

Omim: 613306 Human

SwissProt: Q96BT7 Human

SwissProt: Q80Y20 Mouse

Unigene: 503763 Human

Unigene: 116968 Mouse

Unigene: 440994 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.