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Anti-ACPT/FITC抗体
产品编YB-6289R-FITC
英文名称Anti-ACPT/FITC
中文名称FITC标记的睾丸酸性磷酸酶抗体
别 名Acid phosphatase testicular; Testicular acid phosphatase; PPAT_HUMAN.
Anti-ACPT/FITC抗体
说 明 书100ul
研究领域肿瘤 细胞生物 信号转导 生长因子和** 转录调节因子 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Horse,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Anti-ACPT/FITC抗体分 子 量47kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ACPT
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-ACPT/FITC抗体
产品介绍background:
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is upregulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. ACPT dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. ACPT is predominantly expressed in testis but exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).
Anti-ACPT/FITC抗体Tissue Specificity:
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.
Similarity:
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.
Database links:
UniProtKB/Swiss-Prot: Q9BZG2.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.