产品名称：Anti-MAdCAM-1/FITC抗体

Anti-MAdCAM-1/FITC抗体

产品编号YB0642R-FITC

英文名称Anti-MAdCAM-1/FITC

中文名称FITC标记的粘膜血管定居因子抗体

别    名Mucosal addressin cellular adhesion molecule-1; Addressin mucosal; hMAdCAM 1; MACAM1; Mucosal addressin cell adhesion molecule 1; Mucosal vascular addressin cell adhesion molecule 1; MADCA_RAT.  

Anti-MAdCAM-1/FITC抗体

说 明 书100ul  

研究领域肿瘤  心血管  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量40kDa

Anti-MAdCAM-1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from rat MAdCAM-1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MAdCAM-1/FITC抗体

产品介绍background:

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function:

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. Anti-MAdCAM-1/FITC抗体t can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity).

Subunit:

Homodimer (Probable).

Subcellular Location:

Membrane; Single-pass type I membrane protein.

Tissue Specificity:

Detected in Peyer patches and mesenteric lymph nodes but not in spleen.

Similarity:

Contains 3 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 17123 Mouse

SwissProt: Q61826 Mouse

Unigene: 391556 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MAdCAM-1（粘膜血管定居因子或黏膜地址素细胞黏附分子）、CD44等均参与癌症和肿瘤细胞与血管内皮的相互作用，与癌症和肿瘤细胞一起穿过血管内皮而进入血管内，参与血行播散转移