产品名称：Anti-muscarinic Acetylcholine Receptor 1/FITC抗体

Anti-muscarinic Acetylcholine Receptor 1/FITC抗体

产品编号YB1150R-FITC

英文名称Anti-muscarinic Acetylcholine Receptor 1/FITC

中文名称FITC标记的毒蕈碱型乙酰胆碱受体M1抗体

别    名muscarinic acetylcholine receptor; M-AChR M1; Muscarinic Acetylcholine Receptor 1;cholinergic receptor, muscarinic 1; Chrm1; Chrm-1; M1; M1R; Muscarinic Acetylcholine receptor M1; Cholinergic receptor muscarinic 1; CHRM 1; CHRM1; HM 1; HM1; M1; M1 muscarinic cholinergic receptor; MGC30125; Muscarinic acetylcholine receptor M1; Acetylcholine receptor(M1).  

Anti-muscarinic Acetylcholine Receptor 1/FITC抗体

说 明 书100ul  

研究领域神经生物学  细胞膜受体  G蛋白偶联受体  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Pig, Cow, Horse,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量51kDa

细胞定位细胞膜

Anti-muscarinic Acetylcholine Receptor 1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human muscarinic Acetylcholine Receptor 1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-muscarinic Acetylcholine Receptor 1/FITC抗体

产品介绍background:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008].

Function:

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subunit:

Interacts with GPRASP2.

Subcellular Location:

Cell membrane; Multi-pass membrane protein. Anti-muscarinic Acetylcholine Receptor 1/FITC抗体Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Similarity:

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.

Database links:

Entrez Gene: 1128 Human

Entrez Gene: 12669 Mouse

Entrez Gene: 25229 Rat

Omim: 118510 Human

SwissProt: P11229 Human

SwissProt: P12657 Mouse

SwissProt: P08482 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

AChR M1 毒蕈碱型乙酰胆碱受体M1,属于G蛋白偶联受体家族成员，主要分布于**神经系统和周围神经系统，乙酰胆碱与受体结合后诱导其功能：抑制酰苷酸环化酶、降解磷酸肌醇、膜钾离子通道开放.