产品名称：Anti-Livin/FITC抗体

Anti-Livin/FITC抗体

产品编号YB-0738R-FITC

英文名称Anti-Livin/FITC

中文名称FITC标记的凋亡抑制蛋白抗体

别    名Baculoviral IAP repeat containing 7; Baculoviral IAP repeat containing protein 7; BIRC 7; BIRC7; BIRC7_HUMAN; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; Livin inhibitor of apotosis; Melanoma inhibitor of apoptosis protein; ML IAP; MLIAP; RING finger protein 50; RNF 50; RNF50; Inhibitors of apoptosis proterins Livin.  

Anti-Livin/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  信号转导  细胞凋亡  细胞周期蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Cow,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量33kDa

Anti-Livin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Livin C-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Livin/FITC抗体

产品介绍background:

Livin is a novel member of the IAP protein family and contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. The two isoforms of Livin appear to have different functions and tissue distributions.

Function:

Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.

Subcellular Location:

Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.

Tissue Specificity:

Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most ***** tissues. Detected in ***** heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines.Anti-Livin/FITC抗体 Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in ***** brain, skeletal muscle and peripheral blood leukocytes.

Similarity:

Belongs to the IAP family.

Contains 1 BIR repeat.

Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 79444 Human

Omim: 605737 Human

SwissProt: Q96CA5 Human

Unigene: 256126 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Livin—属于凋亡蛋白抑制因子家族（inhibitor of apoptosis proteins，IAP）

Livin是凋亡抑制蛋白家族的新成员，主要通过抑制Caspases蛋白发挥抑制细胞凋亡的作用,主要在胎盘组织中表达，同时在一些肿瘤组织中呈高表达，尤其是在黑色素瘤细胞系表达水平*高。

经研究表明，Livin与肿瘤的发生、发展关系密切,是一个有潜在价值的肿瘤标志物，此外，反义Livin以及Livin活性抑制物的研究有望成为肿瘤**的新靶点。