产品名称：Anti-KLF4/FITC抗体

Anti-KLF4/FITC抗体

产品编号YB-1064R-FITC

英文名称Anti-KLF4/FITC

中文名称FITC标记的肠道内富含的Kruppel样因子/上皮锌指蛋白4抗体

别    名Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4; KLF4_HUMAN.  

Anti-KLF4/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  信号转导  干细胞  细胞周期蛋白  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig,

产品应用Flow-Cyt=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量56kDa

Anti-KLF4/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human KLF4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-KLF4/FITC抗体

产品介绍background:

KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.

Function:

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Anti-KLF4/FITC抗体Contributes to the down-regulation of p53/TP53 transcription.

Subunit:

Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).

Subcellular Location:

Nucleus.

Post-translational modifications:

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Similarity:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Database links:

Entrez Gene: 9314 Human

Entrez Gene: 16600 Mouse

Omim: 602253 Human

SwissProt: O43474 Human

SwissProt: Q60793 Mouse

Unigene: 376206 Human

Unigene: 4325 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Klf4（原称GKLF）调节体外細胞的增生与分化，有学者认为：KLF4可能参与消化系统肿瘤的发生及发展过程，多表达与结肠。又称：上皮锌指转录因子（上皮锌指蛋白）Surface skin layer zinc finger protein。