产品详情
  • 产品名称:Anti-IKB beta/FITC抗体

  • 产品型号:Anti-IKB beta/FITC
  • 产品厂商:科研抗体
  • 产品价格:0
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Anti-IKB beta/FITC抗体和抗原之间的结合具有高度的特异性,**组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来,以此作为抗原或半抗原,Anti-IKB beta/FITC抗体通过**动物后获得特异性的抗体,再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的,因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来,以其达到对组织或细胞中的未知抗原进行定性,定位或定量的研究。
详情介绍:

Anti-IKB beta/FITC抗体

产品编号YB-1156R-FITC

英文名称Anti-IKB beta/FITC

中文名称FITC标记的核因子κB抑制蛋白β抗体

别    名I kappa B beta; I-kappa-B-beta; IkappaBbeta; IKB beta; IkB-B; IkB-beta; IKBB; IKBB_HUMAN; IkBbeta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9.  

Anti-IKB beta/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量37kDa

Anti-IKB beta/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human IKB beta

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-IKB beta/FITC抗体

产品介绍background:

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].


Function:

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.


Subunit:

Interacts with THRB (via ligand-binding domain).Anti-IKB beta/FITC抗体 Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.


Subcellular Location:

Cytoplasm. Nucleus.


Tissue Specificity:

Expressed in all tissues examined.


Post-translational modifications:

Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.


Similarity:

Belongs to the NF-kappa-B inhibitor family.

Contains 6 ANK repeats.


Database links:

Entrez Gene: 4793 Human

Entrez Gene: 18036 Mouse

Entrez Gene: 81525 Rat

Omim: 604495 Human

SwissProt: Q15653 Human

SwissProt: Q60778 Mouse

SwissProt: Q9JIA3 Rat

Unigene: 9731 Human

Unigene: 220333 Mouse

Unigene: 8395 Rat



Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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