产品名称：Anti-IFABP/FITC抗体

Anti-IFABP/FITC抗体

产品编号YB0825R-FITC

英文名称Anti-IFABP/FITC

中文名称FITC标记的小肠型脂肪酸结合蛋白抗体

别    名FABP 2; FABP2; FABPI; Fatty acid binding protein 2 intestinal; Fatty acid binding protein intestinal; Fatty acid-binding protein; I-FABP; IFABP; Intestinal fatty acid binding protein 2; MGC133132; FABPI_HUMAN.  

Anti-IFABP/FITC抗体 

说 明 书100ul  

研究领域**学  生长因子和**  糖尿病  结合蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量28kDa

Anti-IFABP/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human IFABP

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-IFABP/FITC抗体

产品介绍background:

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]

Function:

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Anti-IFABP/FITC抗体Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.

Similarity:

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Database links:

Entrez Gene: 2169 Human

Entrez Gene: 14079 Mouse

Entrez Gene: 25598 Rat

Omim: 134640 Human

SwissProt: P12104 Human

SwissProt: P55050 Mouse

SwissProt: P02693 Rat

Unigene: 282265 Human

Unigene: 28398 Mouse

Unigene: 91358 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

小肠脂肪酸结合蛋白(IFABP)主要是在小肠分泌的一种蛋白质,参与了脂肪酸的吸收和代谢。IFABP有可能通过干扰脂肪酸代谢而影响胰岛素敏感性。

IFABP主要用于2型糖尿病相关性的研究。