产品名称：Anti-OPCML/FITC抗体

Anti-OPCML/FITC抗体

产品编号YB1081R-FITC

英文名称Anti-OPCML/FITC

中文名称FITC标记的**样物质结合蛋白/细胞粘附分子样蛋白抗体

别    名opioid binding protein/cell adhesion molecule-like; OPCML; OBCAM; OPCM; 3732419F12; C230027C17; 2900075O15RIK; AI844366; B930023M13RIK; Gm181; IGLON1; MGC99974; OPCM_HUMAN; Opioid-binding protein/cell adhesion molecule.  

Anti-OPCML/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  细胞粘附分子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量35kDa

Anti-OPCML/FITC抗体细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human OPCML

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-OPCML/FITC抗体

产品介绍background:

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Function:

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Subcellular Location:

Cell membrane.

DISEASE:

Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue.Anti-OPCML/FITC抗体 Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Similarity:

Belongs to the immunoglobulin superfamily. IgLON family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 4978 Human

Omim: 600632 Human

SwissProt: Q14982 Human

Unigene: 4817 Human

Unigene: 720580 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

OPCML基因的作用是产生一种能帮助卵巢表面分子粘合在一起的蛋白质，当这一基因关闭后，细胞间的粘合力减弱，此时如细胞加速生长，即有可能产生早期癌变。

经研究发现，OPCML能够增加细胞的黏附能力,抑制癌细胞的增殖,OPCML可能是一个新的抑癌基因.在早期病症中能抑制癌变细胞蛋白质的生成，并有效阻止癌变细胞的生长。