产品名称：Anti-MAGE-1/FITC抗体

Anti-MAGE-1/FITC抗体

产品编号YB-0817R-FITC

英文名称Anti-MAGE-1/FITC

中文名称FITC标记的黑色素瘤相关抗原抗体

别    名MAGE-1 protein; Antigen MZ2 E; MAGE 1 antigen; MAGE1; MAGE1A; MAGEA1; Melanoma antigen 1; Melanoma antigen family A 1 (directs expression of antigen MZ2 E); Melanoma antigen family A 1; Melanoma antigen MAGE 1; Melanoma associated antigen 1; Melanoma associated antigen MZ2 E; MAGA1_HUMAN; MGC9326.  

Anti-MAGE-1/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量34kDa

Anti-MAGE-1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human MAGE-1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MAGE-1/FITC抗体

产品介绍background:

The MAGE 1 gene is a member of the melanoma antigen encoding gene family. These genes encode for HLA-restricted tumor associated rejection antigens recognized by cytotoxic T lymphocytes. Some of these target antigens may be potentially useful for cancer specific immunotherapy. The expression of MAGE genes has been reported not only in melanoma but also in various other malignant tumors such as hepatocellular carcinoma and germ cell tumors.

Function:

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation.Anti-MAGE-1/FITC抗体 May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Subunit:

Interacts with SNW1 and HDCA1.

Subcellular Location:

Cytoplasm. Nucleus.

Tissue Specificity:

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

Similarity:

Contains 1 MAGE domain.

Database links:

Entrez Gene: 4100 Human

Entrez Gene: 17137 Mouse

Entrez Gene: 493750 Rat

Omim: 300016 Human

SwissProt: P43355 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Mage-1表达于正常的黑素细胞和大多数原发及转移的黑色素瘤中，故称：黑色素瘤相关抗原。MAGE-1是重要的肿瘤特异性抗原-MAGE家族成员,近年被认为是一种辨别黑色素病变的有效抗原。 主要用于恶性肿瘤方面的研究。MAGE-1基因属于黑色素瘤抗原编码基因家族，其编码产物表达于各种组织类型的肿瘤中。包括黑色素瘤、神经胶质脑肿瘤、成神经细胞瘤、肾细胞癌等，但正常组织表达量较少货没有。