产品名称：Anti-Hepatitis E Virus ORF3 /FITC抗体

Anti-Hepatitis E Virus ORF3 /FITC抗体

产品编号YB0212R-FITC

英文名称Anti-Hepatitis E Virus ORF3 /FITC

中文名称FITC标记的戊型肝炎病毒抗体

别    名structural protein; immunogenic protein; ORF-3; ORF 3; Protein ORF3; pORF3; phosphoprotein; ORF3 [Hepatitis E virus]; ORF3_HEVHY.  

Anti-Hepatitis E Virus ORF3 /FITC抗体

说 明 书100ul  

研究领域**学  **及病毒  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 HEV

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量13.5kDa

Anti-Hepatitis E Virus ORF3 /FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from HEV ORF3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Hepatitis E Virus ORF3 /FITC抗体

产品介绍background:

The Hepatitis E virus is the causative agent of Hepatitis E. Its taxonomic name is Orthohepevirus A. The viral genome a single-strand of positive-sense RNA that is approximately 7200 bases in length. It encodes 3 proteins (O1, O2, O3), two of which are polyproteins, that is, they are cleaved into fragments which carry out the actual functions of the virus. The O1 protein consists of 7 such fragments, namely Met (Methyltransferase), Y (Y-domain), Plp (Papain like protease), V (proline-rich variable region), X (X-domain, macro-domain), Hel (Helicase), and Rdrp (RNA dependent RNA polymerase). The Pvx domain is a fusion protein consisting of the Plp, V and X domains. The O3 protein is encoded by a single open reading frame (ORF3). The O2 protein encodes the capsid, which is composed of 3 domains, namely the shell domain (S) and two protruding domains (P1, P2). Numbers in the figure indicate positions in the RNA sequence.

Function:

May act as a viral regulatory protein involved in the modulation of mitogenic signaling pathways. May be involved in virion morphogenesis and viral pathogenesis. Expedites the processing and secretion of AMBP from the hepatocyte.

Subunit:

Homodimer. Interacts with host SRC, HCK, FYN, PIK3R3 and GRB2 (via SH3 domain); binding does not activate the kinases. Interacts with host AMBP/bikunin and AMBP/alpha-1-microglobulin peptides.Anti-Hepatitis E Virus ORF3 /FITC抗体 Interacts with host HPX/hemopexin. The phosphorylated form interacts with the unglycosylated capsid protein.

Subcellular Location:

Host cytoplasm, host cytoskeleton. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions.

Post-translational modifications:

Not glycosylated.

Similarity:

Belongs to the hepevirus ORF3 protein family.

Database links:

UniProtKB/Swiss-Prot: O90299

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.