产品名称：Anti-BRI3BP/FITC抗体

Anti-BRI3BP/FITC抗体

产品编号YB-0402R-FITC

英文名称Anti-BRI3BP/FITC

中文名称FITC标记的宫颈癌原基因1/bri3结合蛋白抗体

别    名BRI3-binding protein; HCCR-1; HCCR1; HCCRBP-1; I3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; I3-binding protein; BRI3B_HUMAN; BRI3BP.  

Anti-BRI3BP/FITC抗体   

说 明 书100ul  

研究领域肿瘤  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Bovine,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量28kDa

细胞定位细胞膜

Anti-BRI3BP/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human BRI3BP

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-BRI3BP/FITC抗体

产品介绍background:

BRI3BP is a 251 amino acid multi-pass membrane protein. Though widely expressed, BRI3BP is found at highest levels in brain, kidney and liver where it localizes to the endoplasmic reticulum (ER) and is involved in ER structural dynamics and mitochondrial viability. Possessing pro-apoptotic properties and the ability to potentiate drug-induced apoptosis, BRI3BP overexpression has been shown to enhance caspase-3 and mitochondrial cytochrome c release in etoposide-treated human embryonic kidney 293T cells. The gene encoding BRI3BP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Function:

Involved in tumorigenesis and may function by stabilizing p53/TP53.

Subunit:

Interacts with LETMD1.

Subcellular Location:

Mitochondrion outer membrane; Multi-pass membrane protein (Probable).

Tissue Specificity:

Most abundantly expressed in brain, liver and kidney.Anti-BRI3BP/FITC抗体 Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.

Database links:

Entrez Gene: 140707 Human

Entrez Gene: 76809 Mouse

SwissProt: Q8WY22 Human

SwissProt: Q8BXV2 Mouse

Unigene: 596464 Human

Unigene: 290720 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

人宫颈癌基因（HCCR）是新近确定的一种癌基因，人宫颈癌蛋白： HCCR-1和HCCR-2两种蛋白。HCCR1不仅在宫颈癌组织中表达，而且在人其他肿瘤如白血病、**瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和**癌中均有过度表达，可作为肝癌及乳腺癌诊断的标志物。