产品名称：Anti-HAI-1/FITC抗体

Anti-HAI-1/FITC抗体

产品编号YB-0540R-FITC

英文名称Anti-HAI-1/FITC

中文名称FITC标记的肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体

别    名Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN.  

Anti-HAI-1/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  激酶和磷酸酶  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量55kDa

Anti-HAI-1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human HAI-1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-HAI-1/FITC抗体

产品介绍background:

HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.

Function:

Inhibitor of HGF activator.Anti-HAI-1/FITC抗体 Also acts as an inhibitor of matriptase (ST14).

Subunit:

Interacts with HGFAC.

Subcellular Location:

Secreted.

Similarity:

Contains 2 BPTI/Kunitz inhibitor domains.

Contains 1 LDL-receptor class A domain.

Contains 1 MANSC domain.

Database links:

Entrez Gene: 6692 Human

Omim: 605123 Human

SwissProt: O43278 Human

Unigene: 233950 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HAI-1 是一种含两个 Kunitz 域的跨膜蛋白，可抑制由细胞膜分泌的并且以游离形式存在的 HGFA 。 HAI-1 也可以作用于其它丝氨酸蛋白酶.

HAI-1 主要在胎盘、肾、胰腺、前列腺和小肠，也有报道称 HAI-1 会在肝癌中表达。