产品名称：Anti-Hyaluronidase-1/FITC抗体

Anti-Hyaluronidase-1/FITC抗体

产品编号YB-1235R-FITC

英文名称Anti-Hyaluronidase-1/FITC

中文名称FITC标记的透明质酸酶/玻璃酸酶抗体

别    名HYA1; HYAL PH-20; HYAL PH20; HYAL1; HYAL3; HYAL5; Haase; Hyaluronidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; Hyaluronidase PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; SPAM1;Sperm adhesion molecule 1; Sperm surface protein PH-20; Sperm surface protein PH20; zona pellucida binding. LUCA-3; HYAL1_HUMAN; HYAL 1; Hyal-1; HYAL1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; LUCA1; Lung carcinoma protein 1; MGC45987; NAT6; Plasma hyaluronidase; Tumor suppressor LUCA 1.  

Anti-Hyaluronidase-1/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  激酶和磷酸酶  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量45kDa

Anti-Hyaluronidase-1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from rat Haase

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Hyaluronidase-1/FITC抗体

产品介绍background:

Hyaluronidase degrades hyaluronic acid, which is an important structural proteoglycan found in basement membranes and also extracellular matrices. There are six members of the hyaluronidase family. Hyaluronidase PH20 is a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane and plays a role in sperm penetration through the the hyaluronic acid-rich cumulus cell layer surrounding the oocyte. Abnormal expression of this gene has been implicated in degradation of basement membranes leading to tumor invasion and metastasis.

Function:

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Subcellular Location:

Secreted. Lysosome.

Tissue Specificity:

Highly expressed in liver, kidney, lung and skin.

Anti-Hyaluronidase-1/FITC抗体Similarity:

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Database links:

Entrez Gene: 3373 Human

Entrez Gene: 15586 Mouse

Entrez Gene: 404698 Pig

Entrez Gene: 367166 Rat

Omim: 607071 Human

SwissProt: Q12794 Human

SwissProt: Q91ZJ9 Mouse

SwissProt: Q6RHW4 Pig

SwissProt: Q76HN1 Rat

Unigene: 75619 Human

Unigene: 10305 Mouse

Unigene: 475658 Mouse

Unigene: 124438 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HAase是一种具有高度底物特异性的蛋白酶，使透明质酸产生低分子化作用的酶之总称,可以特异地作用于透明质酸，通过裂解葡萄糖胺和葡萄糖醛酸的分子键而将透明质酸分解为二糖成分，引起透明质酸的解聚和降解，透明质酸分子从胶原细纤维间隙中释放出来并重新分布，主要定位于细胞外基质影响细胞的增殖、分化及迁移,并在胚胎发育和肿瘤发**展过程中发挥作用,因而它在胚胎发育、血管形成、**监视以及肿瘤发**展过程中起着重要作用。